Related Links:
For additional information regarding the ROX Solution, please refer to the following links.
- Venous Admixture in COPD: COPD: Journal of COPD
- Percutaneous Creation of...: Vascular Disease Management
- An Arteriovenous Fistula Increase Exercise Capacity in Patients with COPD: CHEST
Christopher B. Cooper, Bartolome Celli. Venous Admixture in COPD: Pathophysiology and Therapeutic Approaches, COPD, 2008 December; 5(6): 376–381.
The authors discuss in this perspective article the mechanism whereby venous admixture contributes to hypoxemia and reduced oxygen delivery to tissues. They explore methods which could potentially increase mixed venous oxygen content thus ameliorating the deleterious effects of venous admixture. The authors believe this approach to treatment could have significant impact for patients with COPD but should also benefit any patient with chronic hypoxemia that impairs exercise performance.
John L. Faul, Horst Sievert. Percutaneous Creation of Arteriovenous Shunts, Vascular Disease Management, 2008 September/October; 5(5): 128-133.
Discusses the rationale for creating arteriovenous (AV) shunts in humans and describes novel techniques for percutaneous creation of AV shunts in patients. In this study, the acute effects of an AVF on mixed venous oxygen content and arterial oxygenation during hypoxia in pigs were examined. The authors conclude that the creation of an AVF improves oxygen delivery during hypoxia and might benefit patients with respiratory disease.
John L. Faul, Christopher B. Cooper, Juan Galindo, Rodolfo Posada-Valay, Guillermo Elizondo-Riojas, Angel Martinez. An Arteriovenous Fistula Increases Exercise Capacity in Patients with COPD, Chest, 2010 July, 138: 52-57.
The article discusses how an ileofemoral arteriovenous fistula increased 6-minute walking distance in patients with severe COPD, matching the improvement seen with supplemental oxygen. An initial response to supplemental oxygen predicted a therapeutic response to the AVF..
